Archive for the ‘Drug Addiction’ Category
Miami Stem Cell Treatment Center: Leaders in Stem Cell Treatment
(PRWEB) February 27, 2014. The Miami Stem Cell Treatment Center, PC, located in Miami, Ft. Lauderdale, and Boca Raton, Florida, announces a series of free public seminars on the use of stem cells for various degenerative and inflammatory conditions.
Read more on PR Web (press release)
Why Couldn't Minivan Mom Be Stopped? No Law Against 'Crazy,' Experts Say
It may be easy to to ask after the fact why no one intervened before a pregnant South Carolina woman drove a minivan carrying her three young children into the Florida surf on Tuesday. But mental health experts say the … That points to the difficulty …
Read more on NBCNews.com (blog)
Acupuncture and yoga for addict prisoners on Drug Recovery Wings
Prisoners are being offered 'holistic therapies' behind bars including yoga, acupuncture and 'deep tissue massage'. The treatments and courses are being put on to new Drug Recovery Wings for inmates who have problems with drugs or alcohol and want to …
Read more on Daily Mail
Latest Best Drug Rehabilitation Blog Post Focuses on the First Step to …
Individuals struggling with an addiction to alcohol or drugs, as well as their loved ones and friends who want to be part of the solution, should read the latest Best Drug Rehabilitation blog post that focuses on the first step to addiction recovery …
Read more on Midland Daily News (blog)
March is Multiple Sclerosis Awareness Month
Read one of our publications, including MSAA's award-winning magazine, The Motivator, and the recently published annual MS Research Update with the latest developments in MS treatments and research. Attend one of MSAA's educational events for …
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Blood donations drop with temperatures
… said that the actual duration of the needle being in the donor's arm actually only lasts about 15 minutes. Those interested in donating are encouraged to visit their local donation center, which can be found on the Red Cross website's donation …
Read more on KTVQ Billings News
Damage Control
External evidence of heat damage to the crown of the aft fuselage extends over at least 16 ft. from the base of the vertical fin forward to near the body join between the major Section 47 tail unit and the main center fuselage section. However, the …
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Program helps inmates overcome addiction, criminal behavior
… AMedium Text; ALarge Text. Jail inmates graduate from program to combat addiction, criminal behavior. Ten inmates of the Kennebec County Jail Wednesday graduated from a program that tries to stop the cycle of substance abuse and criminal behavior.
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Wash. Addiction-Recovery Centers Losing Funding Under Obamacare
The Affordable Care Act may soon force Washington State alcohol and drug treatment centers to close, according to the head of a Seatte recovery center. Under Obamacare, addiction centers will no longer receive funding from the state to make up …
Read more on National Review Online (blog)
Senate bill aims to expand drug–abuse treatment
The legislation would also give decision-making authority for a patient's addiction treatment, including which type of care and for how long, to a medical professional. Supporters say that stipulation would put treatment … Jamie Bogenschutz …
Read more on Newsday
Hanley Center Committee Members Gather to Plan 19th Annual Family Picnic …
Hanley Center is a nonprofit residential substance abuse treatment center established by the Hanley family as a community resource nearly 30 years ago. Mary Jane and Jack Hanley started with the goal of bringing quality substance abuse treatment to the …
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Question by Kevin7: has the drug GRN-29 improved autism symptoms in mice?
science daily news
Best answer:
Answer by Hαяνεγ βoi 416™
*GRN-529
Agent Reduces Autism-Like Behaviors in Mice: Boosts Sociability, Quells Repetitiveness
ScienceDaily (Apr. 25, 2012) — National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.
GRN-529 is a member of a class of agents that inhibit activity of a subtype of receptor protein on brain cells for the chemical messenger glutamate, which are being tested in patients with an autism-related syndrome. Although mouse brain findings often don’t translate to humans, the fact that these compounds are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers.
“Our findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms,” explained Jacqueline Crawley, Ph.D., of the NIH’s National Institute of Mental Health (NIMH). “Many cases of autism are caused by mutations in genes that control an ongoing process — the formation and maturation of synapses, the connections between neurons. If defects in these connections are not hard-wired, the core symptoms of autism may be treatable with medications.”
Crawley, Jill Silverman, Ph.D., and colleagues at NIMH and Pfizer Worldwide Research and Development, Groton, CT, report on their discovery April 25th, 2012 in the journal Science Translational Medicine.
“These new results in mice support NIMH-funded research in humans to create treatments for the core symptoms of autism,” said NIMH director Thomas R. Insel, M.D. “While autism has been often considered only as a disability in need of rehabilitation, we can now address autism as a disorder responding to biomedical treatments.”
Crawley’s team followed-up on clues from earlier findings hinting that inhibitors of the receptor, called mGluR5, might reduce ASD symptoms. This class of agents — compounds similar to GRN-529, used in the mouse study — are in clinical trials for patients with the most common form of inherited intellectual and developmental disabilities, Fragile X syndrome, about one third of whom also meet criteria for ASDs.
To test their hunch, the researchers examined effects of GRN-529 in a naturally occurring inbred strain of mice that normally display autism-relevant behaviors. Like children with ASDs, these BTBR mice interact and communicate relatively less with each other and engage in repetitive behaviors — most typically, spending an inordinate amount of time grooming themselves.
Crawley’s team found that BTBR mice injected with GRN-529 showed reduced levels of repetitive self-grooming and spent more time around — and sniffing nose-to-nose with — a strange mouse.
Moreover, GRN-529 almost completely stopped repetitive jumping in another strain of mice.
“These inbred strains of mice are similar, behaviorally, to individuals with autism for whom the responsible genetic factors are unknown, which accounts for about three fourths of people with the disorders,” noted Crawley. “Given the high costs — monetary and emotional — to families, schools, and health care systems, we are hopeful that this line of studies may help meet the need for medications that treat core symptoms.”
http://www.sciencedaily.com/releases/2012/04/120425143634.htm
Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism (Abstract)
http://stm.sciencemag.org/content/4/131/131ra51